We are looking for a Principal Scientist with a strong background in immunology to identify new therapeutic opportunities and help shape Xaira’s portfolio.

Identify promising disease areas. Assess unmet needs, disease mechanisms, patient subsets, and the limitations of current treatments.

Find and prioritize targets. Combine human genetics, functional genomics, genome-scale multi-omics datasets, and patient data to develop strong therapeutic hypotheses.

Assess platform fit. Work with molecular design, protein engineering, and functional screening teams to identify opportunities where our platforms could offer a therapeutic advantage.

Evaluate the evidence. Assess causality, the desired direction of target modulation, safety risks, and key knowledge gaps.

Build clear recommendations. Develop concise target assessments covering disease rationale, patient selection, competition, differentiation, and risks.

Track emerging science and competition. Follow publications and clinical results, and monitor the competitive landscape to identify new opportunities and inform priorities.

Use AI tools to analyze multi-modal data.

Lead discovery programs or platform initiatives.

We are looking for someone with:

PhD in immunology or a related field with 6+ years of industry experience in drug discovery, target discovery, preclinical drug development, or translational drug development.

Experience drawing on human genetics, genome-scale multi-omics datasets, and other human data alongside cell biology, disease biology, and clinical findings to evaluate therapeutic hypotheses.

Principal Scientist, Target Discovery & Portfolio Strategy

Responsibilities

Qualification

Required

Benefits

Company

Xairatherapeutics

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