Scientist II, Screening at Profluent · LumiJobs

Responsibilities

Profluent is seeking a motivated, rigorous, and collaborative scientist to establish and lead a centralized gene editor screening function. High-quality experimental data is a core input to our protein design models, and this role will own the screening operations that produce it.
This role centers on building and running a screening core responsible for assay standardization, data quality, and team development. At first, you will support campaigns that generate training and evaluation data for our protein design models, and the scope may grow to cover more programs. You will design, run, and troubleshoot mammalian genome editing assays with NGS readouts in arrayed and pooled formats. You will set the technical standards that make our data reproducible and trustworthy. You will also build and mentor a team of Research Associates, and coordinate closely with Automation, Bioinformatics, Data Science, and Biology to keep the screening pipeline running smoothly from start to finish.
As a leader of the team, you will balance hands-on scientific execution with people management and process development. You will identify, prioritize, and drive infrastructure projects that improve throughput, consistency, and assay sensitivity. You will also work with leadership to shape the long-term scope of the core.
We welcome candidates from diverse backgrounds who share our commitment to revolutionizing biology, driving meaningful innovation, and making a lasting impact on global healthcare.
This role offers a unique opportunity to shape the future of AI-driven protein design while collaborating with a dynamic, interdisciplinary team of experts in machine learning, protein engineering, cell biology, and gene editing.
Build and lead a team of 2–4 Research Associates, including hiring, training, performance management, and career development
Train and mentor staff on aseptic technique, assay execution, and documentation standards
Foster a supportive team culture that prioritizes growth, engagement, and well-being
Prioritize, schedule, and resource cross-functional experiments in coordination with Automation and Bioinformatics
Design, execute, troubleshoot, and analyze mammalian genome editing assays with NGS readouts in arrayed and pooled formats
Onboard new assays and extend existing assays to new enzyme classes
Maintain sample chain of custody from plate mapping through automation, sample preparation, and sequencing submission, partnering with Bioinformatics on data schema and capture

Scientist II, Screening

Responsibilities

Qualification

Required

Company

Profluent

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