Responsibilities

insitro is a physical AI company dedicated to unlocking causal human biology and accelerating the delivery of better medicines to patients. Our unique Virtual HumanTM platform identifies novel, high-impact genetic intervention points, which our TherMLTM platform translates into therapeutics—whether small molecules, biologics, or oligos. With multiple programs in metabolic disease and neuroscience advancing toward the clinic, and our first IND submission slated for the second half of this year, we are at a pivotal inflection point.
As a Senior/ Staff Software Engineer on our Imaging Software team, you will define and expand our data and ML infrastructure across the full data lifecycle — from data generation, high-throughput ML pipelines, to analysis results. You'll build the platform features that make novel in vitro screening modalities and ML-derived phenotypes integral to our discovery workflows, partnering with lab scientists, ML scientists, and our automation teams to turn research prototypes into validated screening workflows that reliably process terabytes of biological data per day. This is a chance to set the technical direction for how imaging, automation, machine learning, and agentic analysis converge in drug discovery.
Based in South San Francisco, this position reports directly to the Director of Imaging, Cellular Machine Learning and offers an in-person hybrid schedule of three days per week.
Platform & Tooling
Platform Enablement: Partner with lab and ML scientists to design, develop, and scale the platform capabilities needed to run and interpret ML-powered high-content imaging screens.
User Tooling: Build and evolve robust tools and interactive interfaces for data exploration, quality assessment, and visualization so scientists can iterate quickly on experimental data.
Architectural Ownership: Own complex, end-to-end projects, making thoughtful architectural trade-offs, and delivering incrementally with long-term maintainability in mind.
Scalability & Data Integrity
Scalability: Scale and harden complex ML workflows, taking them from research prototypes to systems that reliably process terabytes of data per day.
Data Integrity: Set and uphold best-in-class practices for data integrity, lineage tracking, reproducibility, and observability across the entire data lifecycle.
Documentation: Write clear, exemplary technical specifications and documentation that others build on.
Cross-Functional Partnership

Senior/ Staff Software Engineer, Imaging at Insitro · LumiJobs

Senior/ Staff Software Engineer, Imaging

Responsibilities

Qualification

Required

Benefits

Company

Insitro

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