Principal Research Scientist I, In Vivo CAR-T Biology at AbbVie · LumiJobs

Responsibilities

Function as a Principal Investigator within the in vivo CAR Biology in vitro preclinical team by defining original scientific hypotheses and research and development strategies for novel in vivo CAR T-cell therapies.
Anticipate and critically evaluate scientific advances or competitive threats and respond with appropriate new research proposals.
Collaborate with Quantitative Medicine, Biotherapeutics, Genetic Medicine, and Discovery Research mRNA-tLNP groups to design and functionally test novel CAR constructs that address key therapeutic challenges.
Lead laboratory project execution by translating therapeutic hypotheses into actionable plans; defining integrated timelines, milestones, dependencies, deliverables, and ownership; ensuring adherence and accountability; and partnering with workstream authors to flag schedule risks and implement mitigation plans.
Represent project teams by providing stakeholders with clear, timely updates on scientific strategy, experimental progress, key decisions, and project risks.
Mentor/supervise a team of one or more and evaluate the performance of those individuals; is accountable for the effective performance of the team/individuals.
Demonstrate creative 'out of the box' thinking to solve difficult problems and champion new technologies to achieve project goals.
Primary author of novel workflows, publications, presentations, regulatory documents and/or primary inventor of patents.
Present research findings and innovative ideas at leading scientific conferences to strengthen AbbVie’s scientific reputation and engagement with external stakeholders and collaborators.
BS or equivalent education with typically 14+ years of experience; MS or equivalent education with typically 12+ years of experience; or PhD with typically 6+ years of experience in CAR-T discovery research, cell therapy, or immuno-oncology.
Expertise in designing, generating, and preclinically evaluating CAR-T candidates; experience developing next-generation in vivo lentiviral CAR-T platforms is strongly preferred.
Expertise in synthetic biology, T-cell biology, and immuno-oncology applied to CAR design and next-generation in vivo CAR-T platform innovation.

Principal Research Scientist I, In Vivo CAR-T Biology

Responsibilities

Qualification

Required

Preferred

Benefits

Company

AbbVie

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