Scientist, Systems Immunology at AbbVie · LumiJobs

Responsibilities

Analyze scRNA-seq, and CITE-seq, datasets, including quality control, integration, clustering, and cell-type and cell-state annotation.
Integrate patient cohorts with reference atlases and perform differential expression, abundance, and pathway analyses, accounting for donor variation and study design.
Analyze scATAC-seq data to identify differential accessibility, transcription factor motifs, and candidate regulatory programs; integrate accessibility with gene expression to infer peak-to-gene relationships.
Analyze TCR/BCR repertoires, including clonotype assignment, clonal expansion, diversity, V(D)J usage, and sharing across tissues or time points; link clonotypes to matched single-cell profiles.
Analyze bulk RNA-seq and Olink proteomics data and integrate multiomics findings to support target prioritization and biomarker hypotheses; maintain documented, version-controlled workflows and evaluate methods using cloud or high-performance computing.
Collaborate with internal and external scientists to prioritize hypotheses for validation, communicate findings and limitations, and contribute to presentations and publications.
BS or MS degree in computational biology, bioinformatics, genomics, biostatistics, computer science, or a related quantitative field with typically 5-7+ years (BS) or 2-5+ years (MS) of relevant experience.
Hands-on scRNA-seq analysis experience or experience with scATAC-seq or TCR/BCR analysis, with interest in developing expertise across both.
Proficiency in Python and/or R and experience working in Linux-based computing environments.
Experience with commonly used bioinformatics tools and frameworks such as Scanpy, AnnData, Cell Ranger, scvi-tools, DESeq2, GSEA, WGCNA, or related methods.
Working knowledge of statistical analysis, multiple-testing correction, batch effects, and biological replication in high-dimensional datasets.
Ability to translate biological questions into analyses, interpret and communicate results critically, collaborate effectively, and manage multiple priorities with attention to detail.

Scientist, Systems Immunology

Responsibilities

Qualification

Preferred

Benefits

Company

AbbVie

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