Veracyte Senior Scientist at Veracyte leading reagent and analytical method development for NGS-based clinical products. The role involves technical leadership from feasibility through lifecycle support and delivering robust reagent formulations.
Responsibilities
Technical and Project Leadership:
Independently lead complex reagent-development projects from concept through implementation, with ownership of technical strategy, objectives, study design, execution, analysis, risk management, documentation, and delivery against program milestones.
Translate product, assay, manufacturing, quality, and business needs into practical reagent-development plans, technical requirements, decision criteria, and stage-appropriate deliverables.
Independently analyze and interpret complex datasets.
Identify critical path activities, dependencies, resource needs, and emerging risks; adjust plans proactively and escalate issues with clear options and recommended actions.
Provide technical direction to scientists and associates contributing to project work. Define expectations, review experimental plans and data, monitor progress, and help resolve roadblocks without requiring formal people-management responsibility.
Formulation, Characterization, and Analytical Strategy
Lead the development, optimization, and characterization of buffers, enzyme formulations, bead-based reagents, and other multicomponent solutions used in NGS and nucleic acid sample-preparation workflows.
Develop a mechanistic understanding of how raw-material attributes, formulation composition, processing conditions, packaging, storage, and shipping affect reagent stability, manufacturability, and downstream assay performance.
Define critical quality attributes and build fit-for-purpose analytical strategies for raw materials, intermediates, bulk formulations, and finished reagents.
Conceive and evaluate innovative analytical or formulation approaches to improve reagent performance, robustness, scalability, stability, and operational readiness.
Integrate orthogonal physicochemical, biochemical, and functional data to establish meaningful relationships between reagent attributes and NGS performance.
Qualification
Flexible and resilient when prioritiesPhDExperience with bead-based reagents$150What We Can Offer You
Required
A hands-on technical leader who can move comfortably between bench-level detail and program-level strategy.
An independent problem solver who can bring structure to ambiguity and make sound decisions with incomplete or evolving information.
A practical product developer who can balance scientific rigor with program priorities, timelines, manufacturability, quality requirements, and operational constraints.
A trusted scientific partner who influences through expertise, judgment, preparation, and clear communication rather than authority alone.
A collaborative mentor who raises the quality of work performed by others and creates clarity without taking ownership away from individual contributors.
Flexible and resilient when priorities, resources, or technical assumptions change, while maintaining accountability for outcomes.
PhD. in Analytical Chemistry, Biochemistry, Chemistry, Molecular Biology, Chemical Engineering, or a related field with 6+ years of relevant industry experience, or an M.S. with 7+ years of relevant industry experience.
Proven ability to independently lead complex technical projects, including defining strategy, planning and executing studies, and driving decisions through implementation.
Demonstrated experience guiding the technical work of scientists, research associates, or other individual contributors through project leadership, mentoring, or matrixed team leadership.
Experience developing and characterizing chemical or biochemical reagents and developing analytical methods or QC assays, with hands-on experience in NGS, nucleic acid sample preparation, or related molecular diagnostic workflows.
Demonstrated success troubleshooting complex, multivariable technical problems and identifying root cause using hypothesis-driven, data-based approaches.
Experience working under design controls and within an ISO 13485 and/or GMP-regulated environment, including authorship or review of controlled technical documentation.
Preferred
Experience with bead-based reagents, enzymes, surfactants, polymers, or viscous, high-salt, or otherwise challenging formulations.
Working knowledge of additional characterization techniques such as FTIR/Raman, GPC/SEC, ion chromatography, ICP-OES/MS, GC, DSF/nanoDSF, LC-MS, cIEF, or rheometry.
Experience with raw-material qualification, supplier technical management, formulation scale-up, stability-study design, method transfer, and manufacturing investigations.
Experience developing workflows for automation or high-throughput clinical laboratory operations, including consideration of liquid handling, throughput, QC, and operational robustness.
Familiarity with CLIA/CAP laboratory environments and development of reagents or assays for clinical, diagnostic, or other regulated applications.
The final salary offered to a successful candidate will be dependent on several factors that may include but are not limited to years of experience, skillset, geographic location, industry, education, etc. Base pay is one part of the Total Package that is provided to compensate and recognize employees for their work, and this role may be eligible for additional discretionary bonuses/incentives, and restricted stock units.
