Genscript Manager, LNP R&D at GenScript leads the Lipid Nanoparticle R&D team focusing on innovative RNA and nucleic acid delivery technologies. The role includes scientific leadership, technology development, and people management.
Responsibilities
Scientific and Technology Leadership
Lead the development of innovative LNP and nucleic acid delivery platforms for mRNA, DNA, small RNAs, and other therapeutic payloads across diverse research and therapeutic applications.
Drive next-generation LNP development, including novel ionizable lipid design and synthesis, formulation optimization, targeted LNPs, extrahepatic delivery, and tissue- or cell-specific delivery strategies.
Establish technology roadmaps and development strategies that create differentiated LNP capabilities, products, and services.
Partner with the RNA R&D team to develop integrated RNA and delivery solutions for vaccines, gene editing, protein replacement, cell engineering, and other emerging applications.
Provide scientific leadership for LNP formulation design, screening, characterization, optimization, and delivery-performance evaluation.
Monitor emerging technologies, scientific publications, competitive platforms, intellectual-property trends, and industry developments in nucleic acid delivery.
Team Leadership and Development
Build, lead, and develop a high-performing LNP R&D team, with responsibility for workforce planning, hiring, resource allocation, budgeting, performance management, and employee development.
Foster a culture of scientific rigor, innovation, accountability, collaboration, transparency, inclusion, and continuous improvement.
Mentor scientists through regular one-on-one meetings, technical guidance, career-development discussions, and timely, constructive feedback.
Allocate resources effectively to achieve project milestones, platform-development objectives, and organizational priorities.
Qualification
PhD in Pharmaceutical SciencesExperience with particle size/PDIExperience in a CRO/CDMO
Required
PhD in Pharmaceutical Sciences, Chemistry, Biochemistry, Chemical Engineering, Biomedical Engineering, Bioengineering, or a related discipline.
At least 5 years of relevant post-PhD industry or research experience in nucleic acid delivery, drug delivery, lipid nanoparticles, or related technologies.
At least 2 years of direct people-management experience leading scientific or technical teams, including hiring, coaching, performance management, employee development, and resource planning.
Deep scientific expertise in lipid nanoparticle formulation and nucleic acid delivery, particularly RNA delivery.
Demonstrated hands-on experience in LNP formulation, production, optimization, and analytical characterization.
Strong understanding of lipid-based and/or polymeric nucleic acid delivery technologies.
Experience with particle size/PDI, zeta potential, encapsulation efficiency, RNA concentration, lipid composition, morphology, and stability assessment.
Experience evaluating nucleic acid delivery performance in relevant in vitro and/or in vivo models.
Strong understanding of RNA biology and analytical methods for evaluating RNA quality, delivery, and functional expression.
Experience with relevant molecular and cellular methods, which may include RT-qPCR, ELISA, Western blotting, flow cytometry, fluorescence-based assays, gel electrophoresis, capillary electrophoresis, and RNA-quantification methods.
Demonstrated ability to analyze complex data, identify root causes, design effective experiments, and make data-driven development decisions.
Strong project-management and organizational capabilities, with the ability to manage multiple priorities and development programs.
Preferred
Experience in novel ionizable lipid design or synthesis, targeted LNPs, extrahepatic delivery, or cell-specific nucleic acid delivery.
Experience developing LNPs for mRNA therapeutics, vaccines, gene editing, in vivo cell engineering, siRNA, or other nucleic acid modalities.
Experience transitioning technologies from early-stage R&D through scale-up, technology transfer, production, or commercial service launch.
Experience in a CRO/CDMO, biotechnology, pharmaceutical, or life-science service organization.
Experience working directly with customers, external collaborators, or commercial teams on technical development programs.
Demonstrated innovation through new technology development, patents, publications, platform development, or successful product/service launches.
The successful candidate will combine deep scientific expertise with strong leadership and execution. They will be comfortable moving between hands-on scientific problem-solving, technology strategy, team development, cross-functional execution, and customer engagement. Most importantly, they will bring scientific curiosity, ownership, creativity, and urgency to building next-generation LNP technologies that strengthen GenScript's global RNA and nucleic acid delivery capabilities.
