Legendcareers Senior Research Associate at Legend Biotech supporting CAR-T cell therapy development for solid tumors. Responsibilities include executing functional assays and viral vector packaging.
Responsibilities
We are seeking a highly motivated Senior Research Associate to join our interdisciplinary cell therapy team at Legend Biotech, focused on advancing CAR-T cell therapies for solid tumors. This role will support our in vivo CAR-T platform, contributing to preclinical development from construct screening through animal model efficacy studies. You will work with the team to plan, execute, and troubleshoot experimental assays and laboratory methods, including cell-based functional and cytotoxicity assays, multi-color flow cytometry, ELISA and PCR-based assays, and viral vector packaging and titration.
The ideal candidate holds a BS or MS in Immunology, Immuno-Oncology, or a closely related discipline, with 0-5 years of experience in the biotech setting. You are a rigorous scientist who thrives in a fast-paced, collaborative environment and is passionate about translating basic immunology insights into transformative oncology therapies.
Package and titer lentivirus
Design and execute in vitro functional assays for safety and potency
Perform construct screening for CAR design.
Handling and engineering human and murine T cells.
Engineering and maintaining various cancer cell lines for model development.
Analyze and interpret data, troubleshooting, maintain detailed experimental records.
Qualification
A scientist in ImmunologyPrimary human T cell isolationFamiliarity with IncucyteMulticolor flow cytometryStandard molecular biologyPlease note
Required
A scientist in Immunology, Immuno-Oncology, Tumor Immunology, Cancer Biology, or a closely related field.
Candidates with experience in the biotech setting are strongly encouraged to apply.
Primary human T cell isolation, activation, lentiviral transduction, and expansion are required.
Familiarity with Incucyte, MSD, LDH release assay.
Multicolor flow cytometry: panel design, data acquisition (e.g., Attune, Novocyte, Cytek Aurora), and analysis (FlowJo).
Standard molecular biology: PCR/qPCR, lentiviral vector packaging and titration, Western blot.
High-throughput screening of drug candidates in the biotech setting.
Experience in cell-based assay development and troubleshooting.
Experience working with multiple immune cell types (T cell, B cell, myeloid) is a plus.
Knowledge in specific tumor disease area.
Please note: These benefits are offered exclusively to permanent full-time employees. Contractors are not eligible for benefits through Legend Biotech.