AbbVie The Associate Scientist II/Scientist I at AbbVie focuses on automating and optimizing chemical biology and mass spectrometry sample preparation workflows. The role supports proteomics experiments and collaborates with therapeutic teams.
Responsibilities
Work with team members to develop, validate, and implement automated sample preparation workflows for CB&MST activities, with an emphasis on plate-based proteomics sample preparation using cell lines, tissues and other biological matrices.
Develop methods to automate chemical biology sample prep using magnetic bead-based enrichments and liquid handling.
Collaborate with team members to establish, document, and maintain Standard Operating Procedures for routine workflows.
Operate, monitor, and assist with the maintenance and troubleshooting of LC-MS instrumentation and associated laboratory equipment.
Assist with data processing, quality assessment, and data interpretation.
Interface and collaborate with colleagues and project teams in therapeutic areas to determine appropriate samples and amounts required for studies.
Bachelors or Masters in chemistry, biochemistry, chemical biology or related field with typically 3-5+ (BS), or 0-2+ (MS) years of experience.
Hands-on bench skills for preparing samples for mass spectrometry, with a focus in proteomics sample preparation from cell lines and tissues.
Ability to generate proteomics samples in 96-well plates and run samples on LC-MS instrumentation.
Ability to work proficiently with laboratory equipment typically found in a chemical biology, biochemistry, or molecular biology laboratory.
Demonstrated ability to troubleshoot and diagnose problems with common laboratory equipment.
Qualification
Bachelors or Masters in chemistryKey Competencies
Required
Bachelors or Masters in chemistry, biochemistry, chemical biology or related field
3-5+ years experience (BS) or 0-2+ years experience (MS)
Hands-on bench skills for preparing samples for mass spectrometry with focus in proteomics
Ability to generate proteomics samples in 96-well plates and run samples on LC-MS instrumentation
Proficient with laboratory equipment in chemical biology, biochemistry, or molecular biology labs
Demonstrated ability to troubleshoot and diagnose problems with common laboratory equipment
Preferred
Experience utilizing LC/MS for proteomics including current models of Thermo and Bruker mass spectrometers.
Experience with automation such as the Agilent Bravo, Thermofisher KingFisher, and Opentrons Flex.
Ability to conduct different types of proteomics experiments including whole proteomics, phosphoproteomics immunoprecipitation proteomics, and targeted MS, etc.
Experience in basic biochemistry and molecular biology techniques including plate-based assays, SDS-PAGE, western blotting, and mammalian tissue culture is desired.
Ability to conduct bead- and probe-based chemical biology experiments that utilize proteomics as a readout.
Ability to effectively use AI to increase personal and team productivity.
Key Competencies:
Builds strong relationships with peers and cross functionally with partners outside of team to enable higher performance.
