Member of Platform Science (Research Scientist, In-vivo)

San Franciscofull time

On Site

$180k–$380k

H1B: no

Anthrogen Research Scientist (In-vivo) at Anthrogen leads in-vivo research for designed biological systems, including model selection, study design, and data interpretation. The role requires hands-on execution and ownership of experimental quality and animal welfare.

Responsibilities

A molecule can work in a dish and fail in a living system for an entirely different reason. It may not reach the tissue, persist long enough, or act in the biological context we expected. We want a scientist who can distinguish those explanations and design the experiment that tells us what to do next.
You'll own in-vivo research for our designed biological systems, from selecting appropriate models to interpreting exposure, activity, and tolerability together. This is a hands-on scientific role, not just study coordination. You'll work with the rest of Platform and our ML researchers to make the results useful for design, including when a study does not support the original hypothesis.
Define the question each study needs to answer, choose an appropriate model, and establish endpoints and an analysis plan before execution.
Design and execute studies with internal colleagues and external partners as appropriate, maintaining ownership of experimental quality and interpretation.
Connect exposure and tissue distribution to target engagement and functional outcomes, rather than evaluating efficacy in isolation.
Investigate differences between in-vitro and in-vivo behavior and translate them into testable changes to the molecule or experimental approach.
Build reproducible workflows for sample collection, downstream measurements, and analysis, in coordination with the scientists running those assays.
Plan and conduct work within approved animal-care protocols, with appropriate oversight, humane endpoints, and careful use of animals.

Qualification

You can reason about pharmacokineticsYou take experimental design seriouslyDepth in oncologyFull-timeEquity

Required

You can reason about pharmacokinetics, pharmacodynamics, and biological mechanism together, and distinguish insufficient exposure from lack of activity.
You take experimental design seriously: randomization, blinding where feasible, justified sample sizes, and explicit handling of variability.
You combine scientific independence with meticulous execution, documentation, and a strong commitment to animal welfare. Moving quickly does not mean relaxing those standards.

Preferred

Experience evaluating engineered proteins or protein-based systems in vivo.
Depth in oncology, immunology, or another disease area relevant to engineered biological interventions.
Experience developing translational biomarkers or connecting tissue-level measurements to a proposed mechanism of action.
Strong quantitative analysis skills and experience working productively with external research partners.
Full-time, onsite in San Francisco.
Equity: 0.05-0.5%.