Kernalbio Senior Scientist responsible for developing and characterizing lipid nanoparticle (LNP) formulations and manufacturing processes. Support tech transfer and analyze experimental results.
Responsibilities
Develop and characterize novel LNP formulations and components using Dynamic Light Scattering, Ribogreen, HPLC, etc.
Support the design and execution of flow cytometry-related experiments pertaining to LNP screening and optimization.
Screen final formulation buffers and excipients to improve the long-term stability of LNPs
Execute in vivo experiments with LNP compositions
Develop new assays or detailed investigations of specific LNP attributes as required.
Development, optimization, and troubleshooting of LNP/mRNA manufacturing processes at various scales.
Analyze, summarize, and present experimental results to team members and management.
Contribute to maintaining stocks and supplies for operations within the LNP Formulation team.
Participate in technology transfer activities related to manufacturing processes and/or analytical methods to external partner programs.
Maintain up-to-date records and prepare internal reports.
Contribute to technical discussions & intellectual property related to the development and application of Kernal’s proprietary technologies
Qualification
PhD in Chemical EngineeringFamiliarity with ELN and GraphPad PrismPreferredNice To HaveAttention to detail
Required
PhD in Chemical Engineering, Biomedical Engineering, Bioengineering, Pharmaceutics, Chemistry or related field.
PhD with 2 years of industry experience in process development in the context of lipid nanoparticles, polymeric nanoparticles, or similar.
Experience in manufacturing LNPs using Microfluidics, T-mixer, or other inline mixers.
Experience with tangential flow filtration (TFF) and sterile filtration.
Proficiency with related LNP/mRNA analytical techniques (e.g. plate-based fluorescence assays, HPLC, LC/MS)
Proficiency with in vivo LNP testing (IV administration, IVIS imaging, etc.)
Proficiency with biological assays critical for identifying key characteristics or properties of lipid nanoparticles
Familiarity with ELN and GraphPad Prism.
Experience with process modeling and Design of Experiment (DoE) statistical tools.
Preferred: Experience with flow cytometry principles and executing experiments
Nice To Have: Experience with tech transfer to GMP manufacturing.
Attention to detail, ability to multi-task, and complete deliverables within timelines.
