Kernalbio Director, LNP Formulation at Kernal Bio leads development of novel lipid nanoparticle systems for in vivo mRNA delivery. Oversees LNP team and guides RNA delivery strategy with emphasis on IP and key deliverables.
Responsibilities
Oversee the development of novel LNP compositions
Improve existing LNP formulations
Manage company’s LNP team
Advance targeted LNP delivery with novel approaches for in situ mRNA delivery
Oversee physicochemical characterization of LNP formulations
Work closely with internal teams and external collaborators and ensure delivery on key milestones
Guide company’s RNA delivery strategy, with a particular emphasis on IP and key deliverables
Stay up-to-date on RNA delivery literature and prepare technical reports and white papers
Prepare technical documents and manuscripts for regulatory filings, IP prosecution, and publications
Present scientific findings internally and externally at scientific conferences and industry events
Qualification
PhD in chemical engineeringExcellent record keeping skills (eLN)Startup mind-set (innovativeWillingness to learnIndustry experience
Required
PhD in chemical engineering, organic chemistry or a related field
8-10 years of hands-on experience with lipid nanoparticle systems for mRNA and/or siRNA delivery
Experience with targeted LNPs and conjugation of biomaterials
Experience with analytical techniques for LNPs such as HPLC/UPLC, LC-MS, DLS, UV-Vis, fluorescence spectrophotometry, Ribogreen assay, gel electrophoresis, capillary electrophoresis, flow cytometry (CytoFLEX nano, NanoFCM) etc.
Excellent communication skills (oral and written)
Excellent record keeping skills (eLN)
Startup mind-set (innovative, enthusiastic, team player, and problem solver)
Willingness to learn, teach, and grow in a fast-pace environment
Industry experience, strong management skills and basic knowledge of the drug development processes
Proficiency in design and characterization of novel lipids is a plus
Preferred
Proficiency in design and characterization of novel lipids
