Senior Scientist / Associate Director, T Cell Immunology

Required

• PhD in immunology, molecular biology, bioengineering, or a related life-sciences field, with substantial industry experience in cell or gene therapy (typically 6+ years post-PhD for Senior Scientist, 9+ for Associate Director), or an MSc with equivalent hands-on experience.
• Deep hands-on expertise in primary human T cell biology: isolation, activation, expansion, transfection and transduction, and functional characterization.
• Experience with gene editing in primary immune cells (nucleases, base or prime editors, transposons, recombinases/integrases, or equivalent), including how editing outcomes are measured.
• Expertise in multiparameter flow cytometry using antibody panels and fluorescent reporters, including panel design and analysis.
• Fluency with ddPCR, qPCR, NGS library preparation and QC, and interpretation of on/off-target analytics.
• Experience designing and overseeing in vivo mouse studies, including CRO management.
• Excellent communication skills with internal and external stakeholders.
• Advantageous Skills and Experience
• Direct contribution to an IND or equivalent regulatory filing, with first-hand knowledge of the pharmacology and toxicology package.
• NHP study design and oversight, including sampling strategy and interpretation of immunogenicity and biodistribution data.
• Working knowledge of the regulatory landscape for genome-edited cell and gene therapies, including off-target assessment, insertional mutagenesis, and long-term follow-up expectations.