Senior / Principal Scientist, Medicinal Chemistry

Bay Area, Californiafull timeOn Site

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senior

$175k–$224k

H1B: yes

Altos Labs Senior / Principal Scientist, Medicinal Chemistry at Altos Labs to advance small-molecule drug discovery programs. Responsibilities include designing drug-like molecules, synthesizing compounds, and collaborating cross-functionally.

Responsibilities

Drive Drug Discovery Programs: Contribute to the chemistry efforts for one or more drug discovery programs, focusing on designing drug-like molecules and optimizing compounds towards drug development candidate selection.
Collaborate Cross-Functionally: Work closely with a diverse range of functions, including Drug Metabolism and Pharmacokinetics, Structural Biology, Biochemical and Cellular Pharmacology, Machine Learning, Pharmaceutical Sciences, Safety, and disease area Biology.
Design and Synthesize Novel Compounds: Apply innovative structure-based, computational, and property-based design tools and methods, and/or synthesize analogs for molecular targets. This includes conducting multi-step syntheses, retrosynthetic analysis of complex molecules, and troubleshooting synthetic issues internally or with CRO partners.
Analyze and Interpret Data: Utilize strong analytical thinking skills to organize, analyze and communicate structure-activity relationship (SAR) data sets to drive design ideas and impact program direction.
Solve Complex Problems: Design compounds that effectively address challenges related to potency, physical properties, and ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity).
Support Chemistry Operations: Execute synthesis within internal laboratories, collaborate with Contract Research Organizations (CROs), and provide broad general chemistry support to all functions within Altos Labs.
Communicate and Present: Deliver effective presentations and articulate scientific findings clearly to both internal and external stakeholders.
Potential for Leadership: Demonstrate leadership potential towards leading chemistry programs, including managing external CRO chemistry FTEs.

Qualification

Education and ExperienceDrug Discovery AcumenStructure-Based Drug DesignStrong CommunicatorProblem-SolverCollaborative Team PlayerResults-OrientedThe salary range for Redwood CitySenior Scientist ISenior Scientist IIPrincipal Scientist I

Required

Education and Experience: You possess a Ph.D. in Organic Chemistry with 6+ years of post-Ph.D. experience, or equivalent and relevant experience in chemical research, preferably within a biotechnology or pharmaceutical setting.
Expertise in Synthetic/Medicinal Chemistry: You have proven expertise in modern synthetic organic chemistry, demonstrated by a strong track record of lead author publications and/or patents and an understanding of medicinal chemistry principles.
Drug Discovery Acumen: You have experience in the drug discovery process from hit identification, hit-to-lead, and lead optimization.
Structure-Based Drug Design: Experienced with structure-based drug design.
Strong Communicator: You convey strong verbal and written communication skills and a demonstrated ability to deliver effective presentations.
Problem-Solver: You exhibit contemporary expertise and understanding of all aspects of organic chemistry, including modern synthetic methodologies, multi-step synthetic route design, compound purification, and characterization.
Collaborative Team Player: You are highly collaborative, team-oriented, and considerate of the needs of the team.
Results-Oriented: You are fearless in your pursuit of groundbreaking innovations and passionate about creating revolutionary medicines to address unmet patient needs.
The salary range for Redwood City, CA:
Senior Scientist I, Medicinal Chemistry: $174,800 - $224,100
Senior Scientist II, Medicinal Chemistry: $215,200 - $275,900
Principal Scientist I, Medicinal Chemistry: $246,600 - $316,100