Independently develop and execute SPR (Biacore and Carterra platforms) assays to generate objective selection criteria for panels of antibodies, multispecifics, and antibody-like biologics.

Evaluate and integrate protein-protein interaction technologies (e.g., SPR, BLI, ELISA, etc.) to support therapeutic candidate selection, demonstrating strong problem-solving skills.

Implement high-throughput epitope binning for large panels of monoclonal antibodies and develop deep knowledge of antibody sequence/function relationships.

Perform antibody Fc characterization studies to support regulatory submissions.

Identify and solve technical problems independently; explore and develop new approaches to further advance innovative characterization and screening technologies.

Serve as a biologics lead for cross-functional teams and contribute scientific insights into multiple projects across various therapeutic areas; recognized and sought out as an expert in biomolecular interactions within the company and externally.

Provide project updates, analysis and advice to cross-functional teams and senior management.

Present original work internally across departments and at internal/external scientific conferences; may author or co-author peer-reviewed scientific papers or patents.

PhD, MS or BS in Biochemistry, Biomedical Engineering or related field with typically 0-4 years (PhD), 8+ years (MS), or 10+ years (BS) of experience.

Experience in analytical/functional characterization of biologics using Surface Plasmon Resonance (SPR) platforms (e.g., Biacore and Carterra).

Experience of high throughput biologics screening with biochemical, biophysical, and cell-based methods.

Possessing broad technical knowledge of a variety of analytical, biophysical, and structural methods, such as SEC, MS, HDX-MS, X-ray crystallography, DSF, DLS, etc. is a plus.

Senior Scientist I, Biomolecular Interactions

Responsibilities

Qualification

Required

Benefits

Company

AbbVie

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