Alumis Senior Scientist responsible for drug product development focusing on solid oral dosage forms. Leads pre-formulation, formulation selection, and manufacturing process development activities.
Responsibilities
Hands-on pre-clinical formulation development includes identifying vehicles, excipients, and/or new technologies for poorly water-soluble compounds in support of preclinical PKPD, efficacy, and tox studies.
Execute and/or oversee pre-formulation activities including characterization of physicochemical and solid-state properties for investigational small molecules with hands-on instrumental analysis (HPLC/UPLC, DSC, XRPD) and method development.
Work effectively with external CDMOs to develop early-stage drug products and oversee production of clinical trial material in support of clinical timelines.
Experience in formulation development, process optimization for small molecule solid oral dosage forms including modified-release products includes execute/oversee formulation and manufacturing process development activities.
Excellent oral and writing communication skills and flexibility to work in a fast-paced team environment by providing updates (oral and written) clearly and concisely.
Support relevant CMC sections for key regulatory filings including INDs and NDAs. Experience in authoring technical reports and regulatory documents (e.g. IND/NDA) is a plus.
Comfortable in a fast-paced small company environment. Proactively identify project risks and prepare mitigation and contingency plans.
Willing to travel as needed to support ongoing development activities.
Ph.D. degree in Pharmaceutical Sciences, Chemistry, Engineering or related field with a minimum of 8 years or B.S. or M.S. with a minimum of 10+ years related industrial experience.
The salary range for this position is $139,000 USD to $169,000 US annually. This salary range is an estimate, and the actual salary may vary based on the Company’s compensation practices.
This position is located in South San Francisco, CA with three (3) to five (5) days a week in lab. We are not considering remote applicants.
Alumis compensation packages include generous stock option grants for all employees as well as an annual bonus program.
Qualification
PhOR B
Required
Ph.D. degree in Pharmaceutical Sciences, Chemistry, Engineering or related field with a minimum of 8 years related industrial experience
OR B.S. or M.S. with a minimum of 10+ years related industrial experience
