Responsibilities

Lead the Science: Act as the scientific lead for a key segment of our neurodegeneration portfolio. You will shape critical research questions, design robust experiments, and drive studies through to actionable, interpretable conclusions.
Model Disease Biology: Design and execute in vivo studies using rodent models of neurodegeneration, strategically selecting models, timepoints, and endpoints tailored to specific biological questions and program stages.
Analyze Complex Tissue: Process and analyze both rodent and human brain tissue. This includes dissection, regional sampling, fixation, cryopreservation, sectioning, and comprehensive downstream characterization (molecular, biochemical, and histological).
Innovate Quantitative Readouts: Develop and apply precise quantitative readouts for pathology and disease biology, tracking markers such as protein aggregation, neuroinflammation, cell loss, and vascular integrity.
Collaborate Across Disciplines: Partner closely with internal experts—including in vivo pharmacology, histology, molecular biology, computational, and program management teams—as well as external collaborators and CROs to seamlessly deliver on shared timelines.
Champion Scientific Rigor: Establish and promote the highest technical and cultural standards across our scientific functions. You will help embed foundational practices—such as experimental rigor, blinding, randomization, data provenance, and reproducibility—into our day-to-day operations.
Drive Strategic Decisions: Actively contribute to program strategy and high-level decision-making, providing critical input on go/no-go recommendations. We value transparent communication, so you will be expected to flag risks early and candidly.
Ensure Data Integrity: Maintain rigorous, traceable records and structured data capture, ensuring your findings can be easily reviewed, reproduced, and built upon by the wider team.
Stay Ahead of the Curve: Keep a close pulse on the latest neurodegeneration literature and proactively bring relevant external developments to bear on our internal research programs.

Qualification

Core Expertise & CredentialsNeurodegeneration SpecialistDisease Biology Deep-DiveProven Track RecordTechnical & Experimental CapabilitiesHands-on AnalystIn Vivo & ImagingTherapeutic FluencyData-Driven DesignScientific Mindset & AdaptabilityOmics InterestTechnical Foundations

Required

The level of the position will depend on the qualifications of the selected candidate.
Core Expertise & Credentials
Neurodegeneration Specialist: You hold a Ph.D. in Neuroscience (or a related field) backed by 1+ years of post-doctoral or industry research experience focused on neurodegeneration.
Disease Biology Deep-Dive: You bring a robust understanding of neurodegenerative disease biology, including a nuanced perspective on the strengths and limitations of the rodent models used to study it.
Proven Track Record: You have an established publication record in the field and are accustomed to presenting your findings at conferences or similar scientific venues.
Technical & Experimental Capabilities
Hands-on Analyst: You have extensive, practical experience processing and analyzing both rodent and human brain tissue samples.
In Vivo & Imaging: You have practical experience with animal surgeries, behavior, and vascular biology, and are proficient in imaging and behavioral analysis techniques.
Therapeutic Fluency: You have experience working with therapeutic modalities relevant to the Central Nervous System (CNS), such as AAV-based approaches, ASOs, or small molecules.
Data-Driven Design: You possess strong quantitative and statistical judgment, enabling you to design appropriately powered studies, analyze complex data, and interpret results objectively without over-extrapolating.
In Vivo & Imaging: You have practical experience with animal surgeries, behavior, and vascular biology, and are proficient in imaging and behavioral analysis techniques.
Scientific Mindset & Adaptability

Preferred

Omics Interest: You have some exposure to analyzing biological datasets and a strong desire to build deep expertise in transcriptomics, proteomics, or spatial approaches.
Technical Foundations: You possess basic skills in bioinformatics data processing or programming (e.g., Python or R) and are eager to apply these to large-scale data management.
Human Cohort Awareness: You are interested in expanding your knowledge of working with human post-mortem or biopsy samples and the unique challenges of cohort-level data.
Technique Expansion: You are motivated to learn advanced imaging techniques, spatial biology, or high-content quantitative histology to enhance your research.
Collaborative Teamwork: You demonstrate strong potential for growth and a commitment to working effectively within a high-performing, collaborative team environment.
Clear Communicator: You are a clear and effective communicator, capable of presenting technical information to your peers and cross-functional partners.
The salary range for Redwood City:
Exact compensation may vary based on skills, experience, and location.

Scientist, Neurodegeneration at Altos Labs · LumiJobs

Scientist, Neurodegeneration

Responsibilities

Qualification

Required

Preferred

Company

Altos Labs

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