Probably Genetic has built one of the deepest phenotyped genetic disease cohorts in the U.S. by facilitating patients' access to genetic testing. We are now using this rich database for target discovery.

We're hiring a Senior Computational Biologist to own our bio data pipelines and interpretation end-to-end. . You'll take our data from QC through positive control recovery to novel, causal, direction-of-effect target hypotheses, and collaborate closely with our team on prioritizing new data modalities to collect.. In addition, your results will be used by our ML researchers to train ML models on multi-modal data and support target discovery. . This is a hands-on, first-of-its-kind role reporting to our VP of R&D.

Bio data processing and QC: take over, improve and fully automate our in-house pipeline for genetic data analysis

Run power analyses and use your insights to inform which phenotypes and indications we prioritize, how we scale our database, and which data modalities we collect

Prove our data and pipelines recover known gene-phenotype associations and approved target-indication pairs, and replicate them against public resources

Conduct association and causal gene mapping in a selected indication, incl. via rare variant burden tests, colocalization tests, and Mendelian randomization

Partner with ML researchers on data preparation, multi-modal integration and shared evaluation

Hand off prioritized targets to wet lab validation and inform in vitro experimental plans and priorities

Senior Computational Biologist

Responsibilities

Qualification

Required

Benefits

Company

Probablygenetic

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