Scientist / Senior Scientist, Structural Cell Biology

Bay Area, Californiafull timeOn Site

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senior

$149k–$191k

H1B: yes

Altos Labs Scientist / Senior Scientist, Structural Cell Biology at Altos Labs advances scientific programs on brain aging and neurodegeneration using lipid and protein biochemistry approaches. The role involves designing expression constructs, purifying membrane proteins, and characterizing their biophysical properties.

Responsibilities

Design expression constructs and perform recombinant cell culture for membrane protein and membrane-associated protein purification and characterization.
Evaluate the purity, stability, and physical properties of purified proteins.
Develop new protein activity assays and establish SOPs.
Coordinate with CROs for material generation and analysis.

Qualification

PhD in a related fieldA proactiveImmunoassay development (ECL/MSDThe salary range for Redwood CityScientist IScientist IISenior Scientist I

Required

PhD in a related field, such as Biochemistry, Chemistry, Biophysics, or Structural Biology
Demonstrable understanding of biochemistry, including the use of electron microscopy for structural biochemistry.
Excellent communication skills and proven ability to collaborate within a dynamic team.
Demonstrated experience with quantitative binding biophysics (BLI, SPR, or ITC), including kinetic and affinity analysis.
Experience with methods for assessing purity, mass, or stability (mass photometry, SEC-MALS, DLS, analytical SEC, or DSF/thermal stability).
Experience reconstituting membrane or lipid-associated proteins into liposomes or nanodiscs.
Experience with Cryo-EM sample preparation and data analysis workflows.
High level of rigor and precision in experimental design, data recording, and documentation in an ELN.
A proactive, problem-solving attitude with the ability to independently troubleshoot, manage multiple priorities, and deliver under timelines.

Preferred

Experience with AI-assisted protein design pipelines.
Immunoassay development (ECL/MSD, ELISA).
Bioconjugation or synthetic chemistry for lipid, glycan, or fluorophore probes.
The salary range for Redwood City, CA
Scientist I, Scientific Technologies: $136,300 - $174,700
Scientist II, Scientific Technologies: $156,800 - $201,000
Senior Scientist I, Scientific Technologies: $172,400 - $221,000
Exact compensation may vary based on skills, experience, and location.

Company

Altos Labs

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Source: greenhouse

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